What Once Was Old Is New Again

Ketamine-What Is Old Is New Again.

AMPylation: Something Old is New Again

The post-translational modification AMPylation is emerging as a significant regulatory mechanism in both prokaryotic and eukaryotic biology. This process involves the covalent addition of an adenosine monophosphate to a protein resulting in a modified protein with altered activity. Proteins capable of catalyzing AMPylation, termed AMPylators, are comparable to kinases in that they both hydrolyz...

What is old is new again: acetaminophen as a novel approach to treating sepsis.

Omacetaxine as an anticancer therapeutic: what is old is new again.

Omacetaxine mepesuccinate was originally identified more than 35 years ago and initial studies in chronic myeloid leukemia (CML) showed promising activity. It has also been studied in other hematologic and solid tumors as both a single agent and in combination with other treatments. However, the introduction of imatinib and related tyrosine kinase inhibitors (TKIs) abated the clinical developme...

BOOP: what is old, what is new?